The study was published Tuesday in the Journal of the American Medical Association.
Standard mammograms typically take one image of each breast from two positions, while 3-D scans take several images of different layers of each breast. That allows for the detection of tumors that might be hidden under breast tissue and not noticeable on regular images, said Jim Culley, a spokesman for Hologic, which makes mammogram machines, including the combo ones used in the study that take both kinds.
The combined system costs up to about $450,000, or as much as two times more than conventional mammogram machines, according to pricing information provided by MD Buyline, a technology research firm. 3-D scans also are less likely to be covered by insurance.
Hologic helped pay for the study and several authors including Plecha and Friedewald are Hologic consultants and members of the company's scientific advisory board.
A newer Hologic 3-D system uses about the same amount of radiation as standard mammograms, while the equipment used in the study uses slightly more but still a safe amount, Culley said.
The researchers analyzed about two years of data from 13 centers as they switched from conventional mammograms to combined 3-D machines. Culley said doctors using Hologic scanners typically use both 3-D and standard imaging for each patient.
The detection rates were about four cancers per 1,000 conventional scans versus about five cancers per 1,000 combined 3-D scans.
Dr. Gilbert Welch, a professor of medicine at the Dartmouth Institute for Health Policy and Clinical Practice in New Hampshire, said the extra radiation and costs are a concern, and the study can't tell women want they want to know -- if 3-D technology saves lives.
Welch said the results are "likely to be overhyped, leading every hospital in the country to feel pressured to buy a new piece of expensive equipment and -- to recoup their investment -- pressure women to use it."
Robert Smith, senior director for cancer screening at the American Cancer Society, said the extra radiation risks of 3-D mammograms are likely more than offset by the advantage of finding more cancer, but he agreed that more long-term data and cost analyses are needed.