Jered Weaver's wildness led to Boston's next two runs that tied it at 3 after six innings.
In the fifth, Dustin Pedroia singled, Ortiz walked and both advanced on a wild pitch. Pedroia scored on Mike Napoli's groundout.
Xander Bogaerts began the sixth with a walk, took third on a single by Christian Vazquez and scored on a sacrifice fly by Holt.
BRAVES 11, PIRATES 3: Justin Upton hit his 24th home run of the season to spoil Andrew McCutchen's return for Pittsburgh.
Upton's three-run homer off Francisco Liriano (3-10) in the third broke things open early. He added a two-run single off reliever Brandon Cumpton in the fifth as the Braves extended Pittsburgh's losing streak to a season-high seven games.
Jason Heyward went 2 for 5 with three RBI for the Braves while Evan Gattis hit his 19th homer. Atlanta has won five straight.
Aaron Harang (10-7) struck out four without a walk in 8 1/3 innings.
McCutchen went 0 for 4 in his first game back after missing two weeks with fractured cartilage in his ribs. The reigning National League MVP left the game after grounding into a double play in the bottom of the eighth.
NATS 8, D-BACKS 1: In Washington, the Nationals scored six runs in the third inning to run their winning streak to eight games.
Stephen Strasburg (10-10) allowed one run and three hits over a season-high eight innings, and Asdrubal Cabrera's bases-clearing double blew the game open to give the Nationals an overdue breather in what is now their longest winning streak since August 2012.
Strasburg struck out four to give him an NL-leading 198 for the season, besting his previous single-season high of 197 in 2012 -- the year he was shut down early after returning from elbow surgery.
The Nationals sent seven batters to the plate in the third before the Diamondbacks could record an out. Rookie Chase Anderson (7-5) faced six of them, allowing five singles and a walk.
ATHLETICS: Bud Selig will likely leave his tenure as baseball commissioner early next year with one unsettled situation that has him "frustrated."
Oakland still doesn't have the new ballpark he believes they desperately need.
Selig praised all parties after the A's recently reached a 10-year lease agreement with the Oakland-Alameda County Coliseum Authority to stay at the rundown Coliseum. Whether the A's are able to one day build a new stadium at the current Coliseum site or elsewhere in Oakland, Selig will support the team's ideas.
Earlier this year, the City of San Jose appealed a judge's decision throwing out a key argument in its lawsuit against Major League Baseball over the A's plans to relocate to San Jose, where the San Francisco Giants hold territorial rights.
At the January 2012 owners' meetings, Selig said the Bay Area situation was on the "front burner." He appointed a committee in March 2009 to study the issues facing the teams, but never ruled on the matter.
"I know there's been criticism about the length this has taken. I'm proud of everything we've done the last 22 years, but this is one of those things as I look back on it, however, it's complicated, it's very complicated," Selig said. "Now we have litigation, so everything is now on hold. That's just a fact of life once we get in litigation. But let me say at the outset, this team needs a new ballpark. ... Once the litigation's resolved, then we'll all proceed.
METAL DETECTORS: Wearing a navy blue New York Yankees shirt, Jonathan Freedman lined up with other fans outside Gate 2 on Jerome Avenue and East 164th Street. Once he reached the front of the single-file line, he emptied his pockets into a plastic bin and was ushered through a metal detector.
Welcome to Yankee Stadium, where security measures now resemble those at the airport. And starting next season, that will be the case at every ballpark in the big leagues.
As part of MLB's security plan, metal detectors were added at some Yankee Stadium gates beginning Tuesday night, when New York hosted Houston. MLB has been working with the Department of Homeland Security to coordinate safety procedures, and all 30 big league parks will have metal detectors by opening day 2015.
The Yankees tried to prepare fans for the change, announcing last Friday they would start implementing the new system on this homestand. It will remain in place for the rest of the season.
Other stadiums have already put the metal detectors in place, too.
"I'm currently living abroad in Israel, so I'm very proud that they have security here. It's been needed for a long time," the 30-year-old Freedman said. "It took a half a second. It was really fast and thorough and they were very courteous. ... All professional. It was all well done."
Fans were asked to take cellphones and large metal objects out of their pockets before walking through the detectors to enter the ballpark. Those who didn't want to pass through the detectors could choose to be checked by security personnel with a hand-held device.
"It wasn't that terrible," said Matt Lurin, 48. "I think in the past when we used to have to take our hats off and show nothing was underside, and take our stuff out of the pockets, it was the same thing. You're less leaving this to chance now. You have a place to put your metal items. They slid it right by and we walked through. It was no problem."
ALS CHALLENGE: Derek Jeter has been doused inside the New York Yankees' clubhouse after accepting the Ice Bucket Challenge and dishing off to Michael Jordan.
Jeter was sitting on a chair placed on the Yankees logo in the middle of the carpeted locker room when injured New York pitchers CC Sabathia and Masahiro Tanaka dumped a large container of ice water over his head Tuesday before a game against the Houston Astros.
The 40-year-old captain, wearing a T-shirt, shorts, socks and sneakers, grimaced and yelled at the top of his lungs before jumping up with a smile to hug his laughing teammates.
Yankees spokesman Jason Zillo captured the video on his cellphone, and the Yankees provided the footage to MLB.com before tweeting out the link.